Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GUSB | P08236 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11011418 | 0.89 | PDE5A (0.32) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11007757 | 0.84 | MAPT (0.34) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11005181 | 0.84 | METAP2 (0.40) | PDE5AFGFR1FGFR2TYK2 | |
| SCHEMBL11011531 | 0.83 | FGFR1 (0.38) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11010987 | 0.81 | KDM4E (0.39) | PDE5AFGFR1FGFR2FGFR3TSHR | |
| SCHEMBL11009966 | 0.77 | PIK3CD (0.35) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11011131 | 0.77 | MAOB (0.39) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11010174 | 0.77 | CYP17A1 (0.39) | PDE5APIK3CD | |
| SCHEMBL11007618 | 0.75 | PDE5A (0.31) | PDE5AFGFR1FGFR2ALDH1A1 | |
| SCHEMBL11007368 | 0.74 | FGFR1 (0.38) | PDE5ACYP1A2CYP3A4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142075-A2 | Purine derivatives, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |