Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 10/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11011421 | 0.90 | METAP2 (0.40) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL11007768 | 0.84 | METAP2 (0.40) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL11005174 | 0.84 | PDE5A (0.32) | PDE5AFGFR1FGFR2TYK2 | |
| SCHEMBL11011535 | 0.82 | PDE5A (0.42) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL10746879 | 0.78 | METAP2 (0.47) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL11009981 | 0.77 | ENPP1 (0.46) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL11010177 | 0.77 | ENPP1 (0.46) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL4407088 | 0.76 | CYP1A2 (0.44) | METAP2METAP1NPY5R | |
| SCHEMBL11011135 | 0.76 | PDE5A (0.42) | METAP2METAP1PDE5AAURKANPY5R | |
| SCHEMBL11012260 | 0.75 | FGFR1 (0.44) | METAP2METAP1PDE5AAURKANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142075-A2 | Purine derivatives, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |