Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | CFB | P00751 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007474 | 0.92 | NISCH (0.58) | NISCHHTR1DHTR1BADRA2CADRA2A | |
| SCHEMBL10767501 | 0.92 | NISCH (0.58) | NISCHHTR1DHTR1BADRA2CADRA2A | |
| SCHEMBL10765153 | 0.84 | NISCH (0.51) | NISCHHTR1DHTR1BADRA2CADRA2A | |
| SCHEMBL11001474 | 0.78 | NISCH (0.72) | NISCHHTR1DADRA2CADRA2AADRA1A | |
| SCHEMBL11428144 | 0.74 | NISCH (0.55) | NISCHHTR1DHTR1BADRA2CADRA2A | |
| SCHEMBL10764582 | 0.74 | NISCH (0.74) | NISCHHTR1DHTR1BADRA2CADRA2A | |
| SCHEMBL11003828 | 0.73 | NISCH (0.54) | NISCHHTR1DADRA2CADRA2AADRA1A | |
| SCHEMBL10765612 | 0.73 | NISCH (0.54) | NISCHADRA2CADRA2AADRA1AADRA2B | |
| SCHEMBL11006239 | 0.71 | NISCH (0.52) | NISCHHTR1DADRA2CADRA2AADRA2B | |
| SCHEMBL6054462 | 0.70 | NISCH (0.69) | NISCHADRA2CADRA2AADRA1AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4526897-A | Hypertensive agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1985-07-02 | — | — | US | disclosed |
| EP-0072954-A2 | Isoindolin-2-yl-amino-imidazolines and isoindolin-2-yl guanidines, process for their preparation and their use as medicines | Beiersdorf Aktiengesellschaft (DE) | 1983-03-02 | — | — | EP | disclosed |