Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 15/20 | 0.60 |
| ▸ | CA2 | P00918 | 15/20 | 0.60 |
| ▸ | CA12 | O43570 | 14/20 | 0.60 |
| ▸ | CA9 | Q16790 | 14/20 | 0.60 |
| ▸ | CA3 | P07451 | 12/20 | 0.60 |
| ▸ | CA6 | P23280 | 12/20 | 0.60 |
| ▸ | CA7 | P43166 | 12/20 | 0.60 |
| ▸ | CA13 | Q8N1Q1 | 12/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 12/20 | 0.60 |
| ▸ | CA5B | Q9Y2D0 | 12/20 | 0.60 |
| ▸ | CA4 | P22748 | 11/20 | 0.60 |
| ▸ | CA5A | P35218 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879988 | 0.78 | CISD1 (0.59) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL31670552 | 0.77 | CA12 (0.71) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL31717970 | 0.76 | CA12 (1.00) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL574023 | 0.76 | CA12 (1.00) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL10124068 | 0.76 | CISD1 (0.60) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL11842272 | 0.76 | MEN1 (0.51) | CA2ALDH1A1MEN1KMT2A | |
| SCHEMBL1716052 | 0.75 | CISD1 (1.00) | CISD1CA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL11158505 | 0.75 | CA12 (0.96) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL14399052 | 0.74 | CISD1 (0.58) | CISD1CA1CA2CA12CA9 | |
| SCHEMBL11165084 | 0.74 | ALDH1A1 (0.70) | CISD1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| US-4283407-A | ANTIHYPERTENSIVE AGENTS | SCIENCE UNION ET CIE (FR) | 1981-08-11 | — | — | US | disclosed |
| US-4261985-A | REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |