Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 10/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 10/20 | 0.48 |
| ▸ | SLC6A3 known ✓ | Q01959 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11010140 | 0.84 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3KDM4EMAPT | |
| SCHEMBL11012556 | 0.80 | ESR1 (0.51) | KDM4EMAPTBLMPMP22DRD1 | |
| Bromide SCHEMBL11014029 | 0.75 | HTR2A (0.46) | KDM4EMAPTBLMPMP22DRD1 | |
| SCHEMBL11007015 | 0.75 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| Bromide SCHEMBL11268045 | 0.72 | SLC6A2 (0.65) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11272633 | 0.70 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7214229 | 0.68 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL5247004 | 0.66 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL11105104 | 0.66 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3PMP22SMN1; SMN2 | |
| SCHEMBL5246719 | 0.65 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4522946-A | FREE OF EXTRA-PYRAMIDAL SIDE EFFECTS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-06-11 | — | — | US | disclosed |