Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 9/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furacrinic Acid SCHEMBL11008170 | 0.85 | LMNA (0.42) | LMNAMAPTCYP3A4PIM1CSNK2A1 | |
| SCHEMBL11118115 | 0.79 | MAPT (0.36) | LMNAMAPTCYP3A4CA12CA1 | |
| SCHEMBL11746037 | 0.79 | PIM1 (0.53) | LMNAMAPTCYP3A4PIM1CSNK2A1 | |
| SCHEMBL1701238 | 0.73 | PIM1 (0.56) | LMNAMAPTPIM1CSNK2A1CSNK2A2 | |
| SCHEMBL1818472 | 0.73 | PIM1 (0.47) | LMNAMAPTPIM1CSNK2A1CSNK2A2 | |
| SCHEMBL11535872 | 0.70 | NPC1 (0.53) | LMNAMAPTPIM1CSNK2A1CSNK2A2 | |
| SCHEMBL9424948 | 0.70 | PIM1 (0.55) | LMNAMAPTCYP3A4PIM1CSNK2A1 | |
| SCHEMBL11010398 | 0.69 | LMNA (0.45) | LMNAMAPTCYP3A4PIM1CSNK2A1 | |
| SCHEMBL20135967 | 0.69 | ALDH1A1 (0.58) | LMNAMAPTCYP3A4PIM1CSNK2A1 | |
| Hydrochloric Acid SCHEMBL11884345 | 0.68 | LMNA (0.36) | LMNAMAPTCYP3A4PIM1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0122882-A1 | Steroids of the 20-spiroxan series, process for their preparation, pharmaceutical compositions containing them and use of these compositions | CIBA-GEIGY AG (CH) | 1984-10-24 | — | — | EP | disclosed |
| EP-0011818-B1 | MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE | CIBA-GEIGY AG (CH) | 1983-01-19 | — | — | EP | disclosed |
| US-4283407-A | ANTIHYPERTENSIVE AGENTS | SCIENCE UNION ET CIE (FR) | 1981-08-11 | — | — | US | disclosed |
| US-4261985-A | REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0011818-A1 | Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | disclosed |
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |