Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11011359 | 1.00 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCSNK1A1 | |
| SCHEMBL11006375 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DIRAK4 | |
| SCHEMBL11006370 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DIRAK4 | |
| SCHEMBL11156324 | 0.83 | CLK4 (0.36) | PDE4APDE4BPDE4CPDE4DCSNK1A1 | |
| SCHEMBL11156325 | 0.83 | CLK4 (0.36) | PDE4APDE4BPDE4CPDE4DCSNK1A1 | |
| SCHEMBL11160449 | 0.79 | NOD1 (0.54) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL11160447 | 0.79 | NOD1 (0.54) | PDE4APDE4BPDE4CPDE4DMAPK14 | |
| SCHEMBL11146764 | 0.77 | PI4KB (0.65) | MAPK14PI4KB | |
| SCHEMBL11146707 | 0.77 | PI4KB (0.65) | MAPK14PI4KB | |
| SCHEMBL11146705 | 0.77 | PI4KB (0.65) | MAPK14PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4492708-A | Antiviral benzimidazoles | ELI LILLY AND COMPANY (US) | 1985-01-08 | — | — | US | claimed |
| EP-0111993-A2 | Improvements in or relating to benzimidazoles | ELI LILLY AND COMPANY (US) | 1984-06-27 | — | — | EP | claimed |
| US-4492708-A | Antiviral benzimidazoles | ELI LILLY AND COMPANY (US) | 1985-01-08 | — | — | US | disclosed |
| EP-0111993-A2 | Improvements in or relating to benzimidazoles | ELI LILLY AND COMPANY (US) | 1984-06-27 | — | — | EP | disclosed |