Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.30 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013358 | 0.83 | KDM4E (0.33) | ACHENTRK1 | |
| SCHEMBL11459026 | 0.80 | PARP1 (0.35) | ACHENTRK1 | |
| SCHEMBL11011905 | 0.77 | TRPV1 (0.31) | TRPV1 | |
| SCHEMBL11008540 | 0.76 | KDM4E (0.41) | NTRK1 | |
| SCHEMBL11475774 | 0.76 | ITGAV (0.34) | ACHE | |
| SCHEMBL11522467 | 0.75 | TRPV1 (0.36) | TRPV1ACHEATAD2 | |
| SCHEMBL10859927 | 0.73 | HDAC1 (0.43) | NTRK1 | |
| SCHEMBL11459015 | 0.72 | KDM4E (0.39) | — | |
| SCHEMBL11522209 | 0.72 | TRPV1 (0.32) | TRPV1 | |
| SCHEMBL11459937 | 0.71 | SLC9A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4529798-A | Reacting the correcponding lithium, sodium, potassium or magnesium halide compound with a aminonitrile compound | JOHN WYETH & BROTHER LIMITED (GB) | 1985-07-16 | — | — | US | disclosed |
| EP-0054384-B1 | PROCESS FOR PREPARING PYRIDINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1984-06-27 | — | — | EP | disclosed |
| EP-0054384-A1 | Process for preparing pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-06-23 | — | — | EP | disclosed |
| US-4191761-A | ANTISECRETORY AGENTS | JOHN WYETH & BROTHER LTD. (GB) | 1980-03-04 | — | — | US | disclosed |