Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HEXA | P06865 | 2/20 | 0.41 |
| ▸ | HEXB | P07686 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257204 | 0.85 | REN (0.44) | MAPTALDH1A1RENCYP3A4DHFR | |
| SCHEMBL11015615 | 0.81 | BACE1 (0.52) | KMT2AMEN1MAPTALDH1A1REN | |
| SCHEMBL21223476 | 0.73 | REN (0.55) | RENCYP2D6ADRA1A | |
| SCHEMBL11593238 | 0.73 | KMT2A (0.63) | KMT2AMEN1MAPTALDH1A1IKBKB | |
| SCHEMBL16099185 | 0.71 | RXFP1 (0.50) | MEN1ALDH1A1RENCYP1A2CYP3A4 | |
| SCHEMBL4497002 | 0.70 | BACE1 (0.47) | KMT2AMEN1MAPTALDH1A1IKBKB | |
| SCHEMBL27854736 | 0.70 | REN (0.39) | KMT2AMEN1MAP3K14RENTDP1 | |
| SCHEMBL7703237 | 0.70 | BACE1 (0.55) | KMT2AMEN1CYP1A2BACE1RAB9A | |
| SCHEMBL29721960 | 0.70 | NOS2 (0.44) | MAPTALDH1A1RENCYP3A4ADRA1A | |
| SCHEMBL21287461 | 0.70 | NOS2 (0.44) | MAPTALDH1A1RENCYP3A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508722-A | 1-Benzoyl-3-(arylpyridyl)urea compounds | ELI LILLY AND COMPANY (US) | 1985-04-02 | — | — | US | disclosed |
| US-4405552-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0060071-A1 | Improvements in or relating to 1-benzoyl-3-(arylpyridyl)urea compounds | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | disclosed |