Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 8/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019240 | 0.80 | KDM4E (0.46) | MAPTPKMNPSR1L3MBTL1GAA | |
| SCHEMBL11015128 | 0.79 | ALDH1A1 (0.40) | MAPTPKMRAF1NPSR1MAPK14 | |
| SCHEMBL3016567 | 0.78 | MAPT (0.40) | MAPTPKMRAF1NPSR1MAPK14 | |
| SCHEMBL29273316 | 0.78 | NOTUM (0.47) | MAPTPKMRAF1MAPK14L3MBTL1 | |
| SCHEMBL10805519 | 0.77 | GAA (0.32) | MAPTPKML3MBTL1GAAKDM4E | |
| SCHEMBL25202606 | 0.77 | MAPT (0.38) | MAPTPKMNPSR1KDM4ENPC1 | |
| SCHEMBL8779802 | 0.77 | KDM4E (0.40) | MAPTPKMNPSR1L3MBTL1GAA | |
| SCHEMBL281723 | 0.76 | RAF1 (0.42) | MAPTPKMRAF1MAPK14L3MBTL1 | |
| SCHEMBL4062812 | 0.75 | MAPT (0.42) | MAPTPKMRAF1MAPK14L3MBTL1 | |
| SCHEMBL16049428 | 0.74 | MAPT (0.39) | MAPTPKMRAF1NPSR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544655-A | Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide, corresponding compositions, and 3-carboxylic acid lower alkyl ester intermediates | HOFFMANN-LA ROCHE INC. (US) | 1985-10-01 | — | — | US | disclosed |