SCHEMBL11015754

SCHEMBL11015754

CC(=O)Nc1ccc(Cl)c(Br)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
RXFP1 Q9HBX9 1/20 0.46
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
KDM4E B2RXH2 2/20 0.45
HSD17B10 Q99714 1/20 0.45
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
POLB P06746 2/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
RAB9A P51151 1/20 0.42
HPGD P15428 1/20 0.40
LMNA P02545 1/20 0.40
PARP14 Q460N5 1/20 0.40
CXCR1 P25024 1/20 0.40
CXCR2 P25025 1/20 0.40
HDAC1 Q13547 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7001806 0.79 RXFP1 (0.56) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL8558945 0.79 ALDH1A1 (0.47) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL3876475 0.78 ALDH1A1 (0.46) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL11641476 0.78 PKM (0.49) ALDH1A1RXFP1KDM4EHSD17B10MEN1
SCHEMBL5725486 0.78 ALDH1A1 (0.46) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL30216059 0.78 ALDH1A1 (0.46) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL11443101 0.76 ALDH1A1 (0.47) ALDH1A1CA1CA2CA9KDM4E
SCHEMBL5724790 0.75 ALDH1A1 (0.41) ALDH1A1RXFP1CA1CA2CA9
SCHEMBL30487767 0.74 ALDH1A1 (0.58) ALDH1A1CA1CA2CA9KDM4E
SCHEMBL17871105 0.74 ALDH1A1 (0.58) ALDH1A1CA1CA2CA9KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0140271-A2 Iodoacetamides BAYER AG (DE) 1985-05-08 EP disclosed