Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017610 | 1.00 | PDE3B (0.60) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11016212 | 0.81 | PDE3B (0.50) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11016210 | 0.81 | PDE3B (0.50) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11017825 | 0.78 | PDE3B (0.46) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11017821 | 0.78 | PDE3B (0.46) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL10986314 | 0.77 | CYP1A2 (0.72) | LMNAKDM4ECYP1A2HPGDNPC1 | |
| SCHEMBL7280366 | 0.75 | PDE3B (1.00) | PDE3BPDE3ALMNACYP1A2NPC1 | |
| SCHEMBL13126938 | 0.75 | CYP3A4 (0.51) | PDE3BPDE3ALMNANPC1RAB9A | |
| SCHEMBL2604923 | 0.74 | CYP3A4 (0.69) | PDE3BPDE3ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8392726 | 0.74 | CYP3A4 (0.69) | PDE3BPDE3ALMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |