Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017821 | 1.00 | PDE3B (0.46) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11020022 | 0.78 | PDE3B (0.50) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL11020025 | 0.78 | PDE3B (0.50) | PDE3BPDE3APDE2APRMT5WDR77 | |
| SCHEMBL11017610 | 0.78 | PDE3B (0.60) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11017607 | 0.78 | PDE3B (0.60) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11016210 | 0.78 | PDE3B (0.50) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL11016212 | 0.78 | PDE3B (0.50) | PDE3BPDE3ALMNAKDM4ECYP1A2 | |
| SCHEMBL10648271 | 0.77 | PDE3A (0.59) | PDE3BPDE3ALMNACYP1A2RAB9A | |
| SCHEMBL10365361 | 0.73 | CYP11B1 (0.42) | LMNACYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL11017552 | 0.72 | PDE3B (0.65) | PDE3BPDE3ALMNAKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |