Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 7/20 | 1.00 |
| ▸ | PDE2A | O00408 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ADH5 | P11766 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287713 | 0.83 | PDE3B (0.71) | PDE3BPDE3APDE2AMEN1KMT2A | |
| SCHEMBL10553489 | 0.82 | PDE3B (0.69) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL7279874 | 0.81 | PDE3A (0.68) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL7277959 | 0.81 | PDE3B (0.68) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL7319085 | 0.80 | PDE3B (0.67) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL12596036 | 0.79 | PDE3B (0.64) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL10668965 | 0.78 | PDE3B (1.00) | PDE3BPDE3APDE2ALMNAMEN1 | |
| SCHEMBL10650257 | 0.77 | PDE3B (0.62) | PDE3BPDE3APDE2ALMNACYP1A2 | |
| SCHEMBL3452908 | 0.77 | LMNA (0.80) | PDE3BPDE3ALMNAMEN1KMT2A | |
| SCHEMBL7280421 | 0.76 | PDE3B (0.61) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | claimed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | claimed |
| EP-0125749-B1 | IMIDAZOLYL-PYRIDAZINONES | WARNER-LAMBERT COMPANY (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| US-4693996-A | SYNERGISTIC MIXTURE OF IMIDAZOLYL-PHENYL-PYRIDAZINONE AND INDANYL-ADENOSINE | WARNER-LAMBERT COMPANY (US) | 1987-09-15 | — | — | US | disclosed |
| US-4521416-A | 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0125749-A2 | Imidazolyl-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1984-11-21 | — | — | EP | disclosed |
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |