Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11035426 | 0.92 | EGFR (0.66) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL11015930 | 0.84 | EGFR (0.59) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL11646450 | 0.84 | EGFR (0.59) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL13620456 | 0.84 | EGFR (0.61) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL2951112 | 0.83 | RAB9A (0.77) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL4451956 | 0.82 | EGFR (1.00) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL11014875 | 0.81 | RAB9A (0.62) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL13234463 | 0.80 | RAB9A (0.64) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL11016786 | 0.80 | EGFR (0.57) | EGFRKMT2ARAB9AMEN1NPC1 | |
| SCHEMBL11119624 | 0.79 | RAB9A (0.62) | EGFRKMT2ARAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144098-A1 | Cyclic ureas of isoxazole | SHIONOGI & CO., LTD. (JP) | 1985-06-12 | — | — | EP | disclosed |