Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018593 | 0.92 | TP53 (0.46) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11018206 | 0.91 | CHEK2 (0.61) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11019250 | 0.91 | CHEK2 (0.53) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11018042 | 0.91 | CHEK2 (0.48) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11017857 | 0.84 | ALDH1A1 (0.46) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11018199 | 0.84 | CHEK2 (0.51) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11019245 | 0.83 | CHEK2 (0.44) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11018034 | 0.83 | RHEB (0.39) | TP53MAPTTDP1POLBNPC1 | |
| SCHEMBL11020242 | 0.83 | CHEK2 (0.58) | CHEK2 | |
| SCHEMBL11018770 | 0.83 | KDM4E (0.47) | TP53MAPTTDP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |