Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 19/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018199 | 0.93 | CHEK2 (0.51) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11020242 | 0.91 | CHEK2 (0.58) | CHEK2 | |
| SCHEMBL11018596 | 0.91 | TP53 (0.54) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11018042 | 0.90 | CHEK2 (0.48) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11017857 | 0.85 | ALDH1A1 (0.46) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11020236 | 0.84 | CHEK2 (0.48) | CHEK2 | |
| SCHEMBL11018593 | 0.84 | TP53 (0.46) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11019250 | 0.83 | CHEK2 (0.53) | CHEK2 | |
| SCHEMBL11018034 | 0.82 | RHEB (0.39) | CHEK2F2F10PLGPLAU | |
| SCHEMBL11018770 | 0.82 | KDM4E (0.47) | CHEK2F2F10PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |