Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018034 | 0.93 | RHEB (0.39) | SCDRHEBKDM4EALDH1A1LMNA | |
| SCHEMBL11018770 | 0.92 | KDM4E (0.47) | SCDKDM4EALDH1A1LMNACHEK2 | |
| SCHEMBL11019245 | 0.91 | CHEK2 (0.44) | SCDPDE2ANPC1HPGDRAB9A | |
| SCHEMBL11020057 | 0.91 | CHEK2 (0.46) | SCDPDE2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11036642 | 0.90 | PDE2A (0.41) | SCDPDE2AKDM4ECHRNB2CHRNB4 | |
| SCHEMBL11020236 | 0.90 | CHEK2 (0.48) | PDE2ACHEK2 | |
| SCHEMBL11018042 | 0.85 | CHEK2 (0.48) | KDM4EALDH1A1LMNANPC1HPGD | |
| SCHEMBL11019250 | 0.83 | CHEK2 (0.53) | NPC1RAB9ACHEK2HDAC6L3MBTL1 | |
| SCHEMBL11020909 | 0.83 | PDE7A (0.41) | SCDPDE2AKDM4ELMNANPC1 | |
| SCHEMBL11020063 | 0.83 | CHEK2 (0.56) | SCDCHEK2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |