Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 18/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020242 | 0.92 | CHEK2 (0.58) | CHEK2 | |
| SCHEMBL11018199 | 0.91 | CHEK2 (0.51) | CHEK2PARP1 | |
| SCHEMBL11019245 | 0.91 | CHEK2 (0.44) | CHEK2PDE2A | |
| SCHEMBL11018765 | 0.90 | SCD (0.41) | CHEK2PDE2A | |
| SCHEMBL11036642 | 0.90 | PDE2A (0.41) | CHEK2PARP1PDE2A | |
| SCHEMBL11020057 | 0.89 | CHEK2 (0.46) | CHEK2PDE2A | |
| SCHEMBL11018830 | 0.85 | PDE2A (0.44) | PDE2A | |
| SCHEMBL11020824 | 0.85 | CHEK2 (0.48) | CHEK2PARP1PDE2A | |
| SCHEMBL11018206 | 0.84 | CHEK2 (0.61) | CHEK2 | |
| SCHEMBL11019250 | 0.83 | CHEK2 (0.53) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |