Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.71 |
| ▸ | AR | P10275 | 2/20 | 0.71 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.71 |
| ▸ | PPARG | P37231 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | PTGES | O14684 | 1/20 | 0.71 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | ALB | P02768 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25837116 | 0.90 | AKR1C3 (0.70) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL9519146 | 0.88 | PTGS2 (0.69) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL17836951 | 0.86 | PTGS2 (0.71) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL11833600 | 0.86 | PTGS2 (0.67) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL13391124 | 0.85 | PTGS2 (0.66) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL2739295 | 0.85 | PTGS2 (0.66) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL860853 | 0.85 | PTGS2 (0.80) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL4538035 | 0.85 | PTGS1 (0.83) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL27603212 | 0.85 | PTGS2 (0.71) | PTGS2AKR1C3PTGS1AKR1C2AR | |
| SCHEMBL2211250 | 0.85 | PTGS2 (0.66) | PTGS2AKR1C3PTGS1AKR1C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322068-B1 | DERIVATIVES OF THIAZOLIDINE-4-CARBOXYLIC ACID HAVING PHARMACOLOGICAL ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | claimed |
| EP-0254354-B1 | PHARMACEUTICALLY USEFUL DERIVATIVES OF THIAZOLIDINE-4-CARBOXYLIC ACID | ZAMBON S.p.A. (IT) | 1993-03-31 | — | — | EP | claimed |
| US-4952596-A | Derivatives of thiazolidine-4-carboxylic acid having pharmacological activity | ZAMBON S.P.A. (IT) | 1990-08-28 | — | — | US | claimed |
| EP-0322068-A1 | Derivatives of thiazolidine-4-carboxylic acid having pharmacological activity | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | claimed |
| US-4840936-A | ANTIFLAMMATORY, ANALGESIC AGENT TO PREVENT ARRHYTHMIAS | ZAMBON S.P.A. (IT) | 1989-06-20 | — | — | US | claimed |
| EP-0254354-A1 | Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid | ZAMBON S.p.A. (IT) | 1988-01-27 | — | — | EP | claimed |
| EP-4238571-A1 | APPLICATION OF THYMIDINE DERIVATIVE IN PREPARATION OF DRUGS | OnQuality Pharmaceuticals China Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| US-8865130-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865130-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130184258-A1 | Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184258-A1 | Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130052138-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2013-02-28 | — | — | US | disclosed |
| US-20130052138-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2013-02-28 | — | — | US | disclosed |
| EP-0254354-B1 | PHARMACEUTICALLY USEFUL DERIVATIVES OF THIAZOLIDINE-4-CARBOXYLIC ACID | ZAMBON S.p.A. (IT) | 1993-03-31 | — | — | EP | disclosed |
| US-5028603-A | Platelet-Activating Factor Antagonist; Useful In Treatment Of Inflammatory Diseases, Allergic Diseases, Asthma, Respiratory System Disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| US-4952596-A | Derivatives of thiazolidine-4-carboxylic acid having pharmacological activity | ZAMBON S.P.A. (IT) | 1990-08-28 | — | — | US | disclosed |
| EP-0322068-A1 | Derivatives of thiazolidine-4-carboxylic acid having pharmacological activity | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |
| US-4840936-A | ANTIFLAMMATORY, ANALGESIC AGENT TO PREVENT ARRHYTHMIAS | ZAMBON S.P.A. (IT) | 1989-06-20 | — | — | US | disclosed |
| EP-0316456-A1 | ESTER-SUBSTITUTED THIENOTRIAZOLODIAZEPINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-24 | — | — | EP | disclosed |
| EP-0254354-A1 | Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid | ZAMBON S.p.A. (IT) | 1988-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184258-A1 | Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels | SCNN1G, KCNN3, KCNN2 | PTGS2 1062/4885AKR1C3 2695/4885PTGS1 1096/4885 |
| US-20130052138-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885AKR1C3 2317/4885PTGS1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.