Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MATK | P42679 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025809 | 0.89 | MAPKAPK3 (0.45) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10866859 | 0.78 | KCNH2 (0.41) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL11023386 | 0.77 | KCNH2 (0.43) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10754015 | 0.74 | CSNK2A2 (0.42) | CSNK2A1KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL10530538 | 0.73 | KCNH2 (0.43) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL11036161 | 0.72 | CYP1A2 (0.47) | TSHRDYRK1AUSP2KDM4EHPGD | |
| SCHEMBL10913879 | 0.72 | CYP1A2 (0.47) | USP2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10912987 | 0.71 | MAPKAPK3 (0.36) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10757080 | 0.70 | KCNH2 (0.45) | KCNH2KDM4EHPGDHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10862782 | 0.70 | KCNH2 (0.41) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |