Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TOP1 | P11387 | 12/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | MATK | P42679 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020193 | 0.89 | MAPKAPK3 (0.38) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10859996 | 0.77 | KCNH2 (0.53) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL11022831 | 0.76 | MAPKAPK3 (0.45) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10754015 | 0.76 | CSNK2A2 (0.42) | CSNK2A1ALDH1A1 | |
| SCHEMBL10913879 | 0.70 | CYP1A2 (0.47) | ALDH1A1 | |
| SCHEMBL11036161 | 0.70 | CYP1A2 (0.47) | DYRK1AALDH1A1 | |
| SCHEMBL11023386 | 0.70 | KCNH2 (0.43) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL9524145 | 0.69 | CSNK2A1 (0.36) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10530538 | 0.68 | KCNH2 (0.43) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 | |
| SCHEMBL10909706 | 0.67 | PIM1 (0.47) | MAPKAPK3PIM1CDK2FLT4CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |