Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.35 |
| ▸ | PLK1 | P53350 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.31 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrous Acid SCHEMBL11021890 | 1.00 | NEK2 (0.35) | NEK2PLK1CYP1A2LRRK2MAP2K4 | |
| SCHEMBL182613 | 0.78 | NEK2 (0.51) | NEK2PLK1CYP1A2RPS6KA5 | |
| SCHEMBL10212372 | 0.78 | NEK2 (0.35) | NEK2PLK1CYP1A2LRRK2MAP2K4 | |
| SCHEMBL182614 | 0.78 | NEK2 (0.51) | NEK2PLK1CYP1A2RPS6KA5 | |
| SCHEMBL17792470 | 0.74 | AKR1C3 (0.44) | CYP1A2ADORA2AADORA2BDYRK1A | |
| SCHEMBL181661 | 0.74 | KIF11 (0.46) | CYP1A2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL29955660 | 0.74 | KIF11 (0.46) | CYP1A2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL4516170 | 0.70 | PDPK1 (0.49) | NEK2CYP1A2LRRK2ADORA2AADORA2B | |
| SCHEMBL16308650 | 0.69 | KIF11 (0.50) | CYP1A2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL12595307 | 0.69 | NEK2 (0.48) | NEK2PLK1CYP1A2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073939-B2 | Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-20120190709-A1 | Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190709-A1 | Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof | BMX, MET, ABL1 | NEK2 1730/4885PLK1 3162/4885CYP1A2 2336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.