Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527585 | 0.84 | CCNB2 (0.35) | TP53MAPTPOLBBRD4DDB1 | |
| SCHEMBL10923242 | 0.79 | NPSR1 (0.36) | TP53MAPTPOLBALDH1A1BRD4 | |
| SCHEMBL10921844 | 0.79 | ACP1 (0.34) | TP53MAPTALDH1A1BRD4CREBBP | |
| SCHEMBL10919300 | 0.79 | TP53 (0.39) | TP53MAPTPOLBIDO1SIRT2 | |
| SCHEMBL10919995 | 0.77 | CREBBP (0.41) | TP53MAPTPOLBIDO1SIRT2 | |
| SCHEMBL10921258 | 0.72 | KDM4E (0.36) | TP53MAPTPOLBALDH1A1BRD4 | |
| SCHEMBL10919563 | 0.66 | CRBN (0.38) | MAPTALDH1A1DDB1CRBNHSD17B10 | |
| SCHEMBL28230957 | 0.64 | ALDH1A1 (0.53) | TP53IDO1ALDH1A1BRD4CREBBP | |
| SCHEMBL29959887 | 0.64 | ALDH1A1 (0.53) | TP53IDO1ALDH1A1BRD4CREBBP | |
| SCHEMBL10525166 | 0.64 | CCNB2 (0.37) | TP53MAPTPOLBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167045-A1 | Benzo[c][1,8]naphthyridines, process for their preparation and their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | disclosed |