Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526975 | 0.80 | CCNB2 (0.42) | CRBNDDB1KDM4ESMN1; SMN2PARP1 | |
| SCHEMBL10923229 | 0.75 | CRBN (0.43) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL10919300 | 0.69 | TP53 (0.39) | ALDH1A1TDP1MAPTPDE3BPDE3A | |
| SCHEMBL10527413 | 0.67 | CCNB2 (0.37) | CRBNDDB1PARP1CCNB2CDK1 | |
| SCHEMBL10527877 | 0.67 | KAT2B (0.37) | CRBNDDB1PARP1CCNB2CDK1 | |
| SCHEMBL10921893 | 0.67 | KDM4E (0.31) | CRBNDDB1KDM4EALDH1A1TDP1 | |
| SCHEMBL10919995 | 0.67 | CREBBP (0.41) | ALDH1A1TDP1MAPT | |
| SCHEMBL11023219 | 0.66 | TP53 (0.37) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL8944351 | 0.66 | CYP2C19 (0.47) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL28650763 | 0.64 | CRBN (0.52) | CRBNDDB1NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167045-A1 | Benzo[c][1,8]naphthyridines, process for their preparation and their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | claimed |
| EP-0167045-A1 | Benzo[c][1,8]naphthyridines, process for their preparation and their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | disclosed |