Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426429 | 0.97 | APOBEC3A (0.48) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5309968 | 0.91 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28183012 | 0.89 | DNM1 (0.44) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| Bromide SCHEMBL1597820 | 0.89 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5428993 | 0.86 | DNM1 (0.46) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7904402 | 0.84 | DNM1 (0.53) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10814018 | 0.83 | APOBEC3A (0.44) | APOBEC3AAPOBEC3GSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5432019 | 0.82 | DNM1 (0.56) | SMN1; SMN2MEN1KMT2ATP53MAPK1 | |
| SCHEMBL15889882 | 0.82 | DNM1 (0.56) | SMN1; SMN2MEN1KMT2ATP53MAPK1 | |
| SCHEMBL12620187 | 0.82 | DNM1 (0.56) | SMN1; SMN2MEN1KMT2ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138553-A2 | Purification of esters of alkanoic acids | ELI LILLY AND COMPANY (US) | 1985-04-24 | — | — | EP | disclosed |