Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.88 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1024317 | 0.94 | TSHR (0.88) | TSHRHCAR2CHRM2CHRM4CHRM1 | |
| Acetic Acid SCHEMBL28586247 | 0.94 | TSHR (0.88) | TSHRHCAR2CHRM2CHRM4CHRM1 | |
| SCHEMBL19193 | 0.94 | — | — | |
| SCHEMBL21064874 | 0.94 | TSHR (1.00) | TSHRHCAR2CHRM2CHRM4CHRM1 | |
| Benzene SCHEMBL8104016 | 0.91 | TSHR (0.82) | TSHRHCAR2CHRM2CHRM4CHRM1 | |
| Ammonia Solution, Strong SCHEMBL5086843 | 0.90 | — | — | |
| SCHEMBL3495565 | 0.90 | — | — | |
| Methyl Alcohol SCHEMBL584909 | 0.90 | — | — | |
| SCHEMBL1278490 | 0.90 | — | — | |
| SCHEMBL4431010 | 0.90 | TSHR (0.93) | TSHRHCAR2CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165794-A2 | Light metal (CFx)n electrochemical cells having high current density and high power density | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-12-27 | — | — | EP | disclosed |