Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11027089 | 0.93 | CHRM1 (0.55) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL11024114 | 0.93 | OPRM1 (0.54) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL11024716 | 0.90 | CHRM1 (0.58) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL11024019 | 0.89 | OPRM1 (0.54) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL20986551 | 0.89 | CHRM1 (0.51) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL20986549 | 0.89 | CHRM1 (0.51) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL11023574 | 0.89 | CHRM1 (0.54) | DRD2CHRM1KCNH2OPRM1HTR1A | |
| SCHEMBL11029089 | 0.89 | OPRM1 (0.58) | DRD2CHRM1KCNH2OPRM1HTR7 | |
| SCHEMBL11024037 | 0.89 | OPRM1 (0.58) | DRD2CHRM1OPRM1HTR1AHTR2A | |
| Axamozide SCHEMBL11022863 | 0.89 | OPRM1 (0.60) | DRD2CHRM1KCNH2OPRM1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068261-B1 | N-OXACYCLYL-ALKYLPIPERIDINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |
| EP-0068261-A1 | N-oxacyclyl-alkylpiperidine derivatives, their preparation, pharmaceutical preparations containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-05 | — | — | EP | disclosed |