Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 4/20 | 0.64 |
| ▸ | PTGFR | P43088 | 3/20 | 0.64 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.64 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.59 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.59 |
| ▸ | PTGIR | P43119 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimoprostil SCHEMBL564049 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL8628176 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL15390002 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL6375938 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL15390003 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL1651349 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL11226793 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL11302949 | 0.91 | PTGER3 (0.58) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL23352779 | 0.91 | PTGFR (0.73) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL11079261 | 0.91 | PTGFR (0.73) | PTGER3PTGFRPTGER1TBXA2RPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049853-B1 | PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-02-13 | — | — | EP | disclosed |
| EP-0049853-A1 | Prostaglandin derivatives, their preparation and pharmaceutical compositions | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-04-21 | — | — | EP | disclosed |
| US-4325970-A | ANTIULCER AGENTS, ANTISECRETORY AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-04-20 | — | — | US | disclosed |