Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 4/20 | 0.64 |
| ▸ | PTGFR | P43088 | 3/20 | 0.64 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.64 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.59 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.59 |
| ▸ | PTGIR | P43119 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimoprostil SCHEMBL564049 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL11024670 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL8628176 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL15390002 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL15390003 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL1651349 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| Trimoprostil SCHEMBL11226793 | 1.00 | PTGER3 (0.64) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL11302949 | 0.91 | PTGER3 (0.58) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL23352779 | 0.91 | PTGFR (0.73) | PTGER3PTGFRPTGER1TBXA2RPTGER4 | |
| SCHEMBL11079261 | 0.91 | PTGFR (0.73) | PTGER3PTGFRPTGER1TBXA2RPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973498-B1 | GASTROINTESTINAL MUCOSA-ADHERENT PHARMACEUTICAL COMPOSITION | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-01-12 | — | — | EP | disclosed |
| US-6428813-B1 | POLYGLYCEROL FATTY ACID ESTER AND/OR A LIPID, A VISCOGENIC AGENT, LOW-SUBSTITUTED HYDROXYPROPYLCELLULOSE AND ACTIVE INGREDIENT; VISCOUS WITH WATER; LONG RESIDENCE TIME; ANTI-HELICOBACTER PYLORI; ULCERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-06 | — | — | US | disclosed |
| WO-1996016656-A1 | CONDENSED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-06 | — | — | WO | disclosed |
| US-4866205-A | Prostaglandin intermediates | HOFFMAN-LA ROCHE INC. (US) | 1989-09-12 | — | — | US | disclosed |
| US-4707555-A | Prostaglandin intermediates | HOFFMANN-LA ROCHE INC. (US) | 1987-11-17 | — | — | US | disclosed |
| US-4558140-A | Cyclopenta[b]furan-2-ones | HOFFMANN-LA ROCHE INC. (US) | 1985-12-10 | — | — | US | disclosed |