Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | UPP1 | Q16831 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815675 | 0.78 | KDM4E (0.56) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11018436 | 0.76 | KDM4E (0.46) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL10964639 | 0.76 | CYP1A2 (0.40) | ALDH1A1MAPTCYP1A2CYP3A4BRD4 | |
| SCHEMBL11026225 | 0.75 | KDM4E (0.45) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11019918 | 0.73 | KDM4E (0.42) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11024172 | 0.73 | KDM4E (0.42) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11019126 | 0.73 | POLB (0.45) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11021108 | 0.73 | GAA (0.43) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL11023239 | 0.69 | KDM4E (0.41) | KDM4EATMPOLBALDH1A1GAA | |
| SCHEMBL5223628 | 0.65 | CYP1A2 (0.48) | KDM4EPOLBALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |