Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 9/20 | 0.41 |
| ▸ | ACACA | Q13085 | 7/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17130313 | 0.80 | DRD2 (0.44) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL6221463 | 0.78 | CKS1B (0.43) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL6221470 | 0.78 | CKS1B (0.43) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL21739082 | 0.78 | GFER (0.41) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL28805974 | 0.76 | DRD2 (0.43) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL10682348 | 0.75 | KMT2A (0.51) | DRD2CKS1BSKP1SKP2ACACB | |
| SCHEMBL8298777 | 0.75 | CKS1B (0.51) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL5462244 | 0.74 | LMNA (0.56) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL7390418 | 0.74 | LMNA (0.56) | DRD2CKS1BSKP1SKP2KDM4E | |
| SCHEMBL7391016 | 0.74 | LMNA (0.56) | DRD2CKS1BSKP1SKP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |