Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024699 | 0.91 | POLB (0.52) | SMN1; SMN2TP53POLBALDH1A1CYP3A4 | |
| SCHEMBL11026260 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53ALDH1A1DRD2USP2 | |
| SCHEMBL11200519 | 0.79 | POLB (0.61) | POLBALDH1A1DRD2DRD3HTT | |
| SCHEMBL11027232 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1CYP3A4LMNA | |
| SCHEMBL8256720 | 0.77 | HRH3 (0.53) | SMN1; SMN2TP53ALDH1A1MAPTMAPK1 | |
| SCHEMBL25603604 | 0.76 | POLB (0.57) | SMN1; SMN2POLBDRD2DRD3CYP3A4 | |
| SCHEMBL11024718 | 0.74 | CYP2C19 (0.49) | SMN1; SMN2TP53POLBALDH1A1DRD3 | |
| SCHEMBL5956990 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1USP2HTT | |
| SCHEMBL12788692 | 0.73 | POLB (0.64) | POLBALDH1A1LMNAHRH3 | |
| SCHEMBL13600585 | 0.73 | POLB (0.53) | SMN1; SMN2TP53POLBALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |