Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788692 | 0.82 | POLB (0.64) | POLBKMT2AALDH1A1CYP2C19KDM4E | |
| SCHEMBL11024699 | 0.81 | POLB (0.52) | POLBKMT2AALDH1A1FAAHCYP2C19 | |
| SCHEMBL657440 | 0.79 | POLB (0.59) | POLBKMT2AHTTFAAHNPSR1 | |
| SCHEMBL11024979 | 0.79 | SMN1; SMN2 (0.53) | POLBHTTALDH1A1DRD2DRD3 | |
| SCHEMBL13176215 | 0.78 | POLB (1.00) | POLBKMT2AHTTALDH1A1KDM4E | |
| SCHEMBL25603604 | 0.78 | POLB (0.57) | POLBKMT2AFAAHDRD2DRD3 | |
| SCHEMBL22892752 | 0.78 | POLB (0.57) | POLBKMT2AHTTFAAHCYP2C19 | |
| SCHEMBL8418345 | 0.78 | POLB (0.70) | POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL296688 | 0.78 | CYP1A2 (0.54) | KMT2AALDH1A1KDM4EDRD3 | |
| SCHEMBL6316085 | 0.77 | CYP2D6 (0.42) | POLBKMT2AHTTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |