Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256720 | 0.98 | HRH3 (0.53) | SMN1; SMN2TP53ALDH1A1HRH3ACHE | |
| SCHEMBL11025226 | 0.93 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53ALDH1A1HRH3ACHE | |
| SCHEMBL11028517 | 0.88 | CA12 (0.56) | SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL5822282 | 0.86 | CA12 (0.58) | SMN1; SMN2ALDH1A1GAAMAPTCYP1A2 | |
| SCHEMBL6196093 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53ALDH1A1HRH3ACHE | |
| SCHEMBL17525452 | 0.82 | KDM4E (0.54) | SMN1; SMN2TP53ACHEGAAMAPT | |
| SCHEMBL18628066 | 0.81 | ACHE (0.55) | SMN1; SMN2TP53ALDH1A1HRH3ACHE | |
| SCHEMBL5230823 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53ALDH1A1HRH3ACHE | |
| SCHEMBL11026260 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53ALDH1A1HRH3GAA | |
| SCHEMBL16353594 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53ALDH1A1HRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |