Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 2/20 | 0.81 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.81 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.81 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
| ▸ | TDO2 | P48775 | 4/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025262 | 0.92 | PRKAG1 (0.69) | PRKAG1PRKAA1PRKAB1IP6K1PRKAB2 | |
| SCHEMBL42946 | 0.90 | PRKAG1 (1.00) | PRKAG1PRKAA1PRKAB1IP6K1PRKAB2 | |
| SCHEMBL45039 | 0.87 | PRKAG1 (0.75) | PRKAG1PRKAA1PRKAB1IP6K1PRKAB2 | |
| SCHEMBL11025424 | 0.86 | PRKAG1 (0.61) | PRKAG1PRKAA1PRKAB1IDO1TDO2 | |
| SCHEMBL11940917 | 0.83 | PRKAG1 (0.59) | PRKAG1PRKAA1PRKAB1IP6K1 | |
| SCHEMBL11026964 | 0.80 | PRKAG1 (0.60) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL11024989 | 0.80 | PRKAG1 (0.54) | PRKAG1PRKAA1PRKAB1IDO1TDO2 | |
| SCHEMBL44986 | 0.79 | PRKAG1 (0.81) | PRKAG1PRKAA1PRKAB1IP6K1IDO1 | |
| SCHEMBL45587 | 0.79 | PRKAG1 (0.57) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL45770 | 0.77 | PRKAG1 (0.61) | PRKAG1PRKAA1PRKAB1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | disclosed |
| EP-2668165-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101068-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | PRKAG1 2822/4885PRKAA1 2934/4885PRKAB1 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.