Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.84 |
| ▸ | REN | P00797 | 12/20 | 0.67 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.63 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.63 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.63 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.63 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.63 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025093 | 0.88 | REN (0.76) | KLK5REN | |
| SCHEMBL11026683 | 0.88 | REN (0.72) | KLK5REN | |
| SCHEMBL18171935 | 0.87 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL7319373 | 0.87 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL28376535 | 0.87 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL8073093 | 0.87 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL30789039 | 0.87 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL23106755 | 0.83 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL22962098 | 0.83 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B | |
| SCHEMBL18229265 | 0.83 | REN (0.68) | KLK5RENPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077029-B1 | RENIN INHIBITORY PEPTIDES | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4384994-A | HYPOTENSIVE AND HYPOALDOSTERONE AGENTS | MERCK & CO., INC. (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0077029-A2 | Renin inhibitory peptides | MERCK & CO. INC. (US) | 1983-04-20 | — | — | EP | disclosed |