Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.68 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.60 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.60 |
| ▸ | CTSS | P25774 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | CTSB | P07858 | 1/20 | 0.58 |
| ▸ | CTSK | P43235 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073093 | 1.00 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL28376535 | 1.00 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL30789039 | 1.00 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL7319373 | 1.00 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL23106755 | 0.95 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL18229265 | 0.95 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL22962098 | 0.95 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL6857159 | 0.95 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL1913543 | 0.95 | REN (0.68) | RENKLK5PSEN1PSEN2APH1B | |
| SCHEMBL8080979 | 0.94 | REN (0.62) | RENKLK5PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824755-A | N- tertbutyloxycarbonyl-L- leucyl-L-phenylalanine methyl esters production method | 湖南华腾制药有限公司 | 2019-05-31 | — | — | CN | claimed |
| US-20180298056-A1 | PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-18 | — | — | US | claimed |
| CN-110964085-B | Preparation method of carfilzomib and derivatives thereof | 扬子江药业集团有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-110964085-A | Preparation method of carfilzomib and derivatives thereof | 扬子江药业集团有限公司 | 2020-04-07 | — | — | CN | disclosed |
| US-10544189-B2 | Process for the preparation of (2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4-methylpentanamide | MSN LABORATORIES PRIVATE LIMITED (IN) | 2020-01-28 | — | — | US | disclosed |
| CN-109824755-A | N- tertbutyloxycarbonyl-L- leucyl-L-phenylalanine methyl esters production method | 湖南华腾制药有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109824755-A | N- tertbutyloxycarbonyl-L- leucyl-L-phenylalanine methyl esters production method | 湖南华腾制药有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109824755-A | N- tertbutyloxycarbonyl-L- leucyl-L-phenylalanine methyl esters production method | 湖南华腾制药有限公司 | 2019-05-31 | — | — | CN | disclosed |
| US-20180298056-A1 | PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-18 | — | — | US | disclosed |
| WO-2016170544-A1 | PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-10-27 | — | — | WO | disclosed |
| CN-1196686-C | Method for storing quaternary ammonium salt | TOKUYAMA CORP (JP) | 2005-04-13 | — | — | CN | disclosed |
| CN-1372554-A | Method for preserving quaternary ammonium salts | TOKUYAMA CORP (JP) | 2002-10-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544189-B2 | Process for the preparation of (2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4-methylpentanamide | OPRL1, PNMT, HTR1A | REN 853/4885KLK5 3206/4885PSEN1 60/4885 |
| US-20180298056-A1 | PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE | OPRL1, OPRM1, ADRA1D | REN 734/4885KLK5 3076/4885PSEN1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.