Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 5/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029563 | 0.93 | SLC29A1 (0.47) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11031534 | 0.93 | SLC29A1 (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11029347 | 0.90 | SLC29A1 (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11027412 | 0.88 | SLC29A1 (0.48) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11029641 | 0.87 | PDE4A (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11058079 | 0.85 | HPGD (0.42) | SLC29A1MEN1GAAMAPK1KMT2A | |
| SCHEMBL11049810 | 0.85 | PDE4A (0.40) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11049628 | 0.84 | SLC29A1 (0.43) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2460092 | 0.84 | SLC29A1 (0.45) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11025105 | 0.83 | SLC29A1 (0.47) | SLC29A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |