Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 6/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.33 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029641 | 0.96 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL2460092 | 0.89 | SLC29A1 (0.45) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11029563 | 0.87 | SLC29A1 (0.47) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11046570 | 0.86 | CYP1A2 (0.40) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11031534 | 0.85 | SLC29A1 (0.42) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11048920 | 0.85 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11028065 | 0.85 | SLC29A1 (0.45) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11049547 | 0.84 | SLC29A1 (0.40) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL10972196 | 0.84 | SLC29A1 (0.40) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11062725 | 0.84 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DSLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |