Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 7/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11049628 | 0.91 | SLC29A1 (0.43) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11032824 | 0.91 | SLC29A1 (0.43) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2460092 | 0.91 | SLC29A1 (0.45) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11048512 | 0.91 | SLC29A1 (0.41) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11047084 | 0.90 | PDE4A (0.41) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11049802 | 0.89 | GBA1 (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11029471 | 0.88 | SLC29A1 (0.41) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11049636 | 0.87 | SLC29A1 (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11051583 | 0.87 | SLC29A1 (0.43) | SLC29A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11040761 | 0.86 | SLC29A1 (0.42) | SLC29A1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |