SCHEMBL11028679

SCHEMBL11028679

C=CCOC(=O)Oc1c(Br)cc(C#N)cc1[N+](=O)[O-]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 3/20 0.39
PTP4A3 O75365 2/20 0.35
PTP4A1 Q93096 2/20 0.35
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
MTOR P42345 1/20 0.33
PLK1 P53350 1/20 0.33
PTP4A2 Q12974 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
KDM4E B2RXH2 1/20 0.32
PKM P14618 1/20 0.32
MEN1 O00255 1/20 0.31
TTR P02766 1/20 0.31
ALB P02768 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11031270 0.85 VCAM1 (0.41) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11030903 0.82 VCAM1 (0.39) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11175374 0.82 VCAM1 (0.39) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11027338 0.81 VCAM1 (0.44) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11032697 0.80 TDP1 (0.49) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11028674 0.77 VCAM1 (0.40) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL134588 0.74 TTR (0.39) PTP4A3PTP4A1PTP4A2KDM4EMEN1
SCHEMBL1734088 0.72 VCAM1 (0.51) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL11035522 0.72 VCAM1 (0.45) VCAM1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL10999487 0.72 CYP3A4 (0.39) PTP4A3PTP4A1PTP4A2KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4486222-A POSTEMERGENCE CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1984-12-04 US claimed
EP-0092632-B1 NEW BENZONITRILE DERIVATIVES, METHOD FOR THEIR PREPARATION AND HERBICIDAL COMPOSITIONS CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1985-09-04 EP disclosed
EP-0092632-A1 New benzonitrile derivatives, method for their preparation and herbicidal compositions CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1983-11-02 EP disclosed