Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203262 | 0.90 | HTT (0.56) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL11238168 | 0.80 | HTT (0.59) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL407408 | 0.80 | ADRA2A (0.51) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL10978442 | 0.79 | HTT (0.58) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL12602022 | 0.79 | POLB (0.59) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL9531443 | 0.76 | ALOX5 (0.45) | HTTCA2HTR1ASMN1; SMN2POLB | |
| SCHEMBL450727 | 0.75 | HTT (0.54) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL406531 | 0.75 | HTT (0.61) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL12309752 | 0.75 | POLB (0.62) | HTTCA2ADRA2AADRA1AHTR1A | |
| SCHEMBL5871673 | 0.75 | HTT (0.61) | HTTCA2ADRA2AADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4436914-A | ANTIDEPRESSANTS, ANTICOAGULANTS | SYNTEX (U.S.A.) IC., 3401 HILLVIEW AVE., P.O. BOX 10850 A CORP. OF DE | 1984-03-13 | — | — | US | disclosed |
| EP-0074711-A2 | Benzodioxane-imidazoline compounds, their preparation and use | SYNTEX (U.S.A.) INC. (US) | 1983-03-23 | — | — | EP | disclosed |