Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11451550 | 0.90 | RECQL (0.49) | NPC1RAB9ARECQLALDH1A1HSPB1 | |
| SCHEMBL31194220 | 0.89 | RAB9A (0.66) | NPC1RAB9ARECQLALDH1A1HTT | |
| SCHEMBL4185071 | 0.89 | RAB9A (0.66) | NPC1RAB9ARECQLALDH1A1HTT | |
| SCHEMBL28345439 | 0.84 | HSPB1 (0.46) | NPC1RAB9ARECQLALDH1A1HSPB1 | |
| SCHEMBL28504880 | 0.84 | NPC1 (0.47) | NPC1RAB9ARECQLALDH1A1HSPB1 | |
| SCHEMBL10532607 | 0.83 | MAPT (0.44) | NPC1RAB9ARECQLALDH1A1POLB | |
| SCHEMBL28649512 | 0.83 | NPC1 (0.42) | NPC1RAB9ARECQLALDH1A1HSPB1 | |
| SCHEMBL27585308 | 0.80 | TDP1 (0.50) | NPC1RAB9ARECQLALDH1A1HTT | |
| SCHEMBL17276070 | 0.79 | NPC1 (0.56) | NPC1RAB9ARECQLALDH1A1HSPB1 | |
| SCHEMBL29740003 | 0.79 | P2RX1 (0.45) | NPC1RAB9ARECQLALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4491584-A | ANTIARRHYTHMIA AGENTS | RIKER LABORATORIES (US) | 1985-01-01 | — | — | US | disclosed |
| US-4154941-A | ANTIARRHYTHMIC AGENTS | RIKER LABORATORIES, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4071524-A | Derivatives of urea | RIKER LABORATORIES, INC. (US) | 1978-01-31 | — | — | US | disclosed |