Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 8/20 | 0.53 |
| ▸ | GRIA3 | P42263 | 8/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 7/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.53 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.53 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.53 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5875640 | 1.00 | GRIA1 (0.53) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL6046222 | 1.00 | GRIA1 (0.53) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL26120631 | 0.90 | GRIA1 (0.49) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL18035901 | 0.90 | GRIA1 (0.49) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL14074121 | 0.88 | GRIA1 (0.47) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL18035913 | 0.88 | GRIA1 (0.47) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL18035914 | 0.84 | GRIA1 (0.47) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL18035897 | 0.83 | GRIA1 (0.44) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL2971635 | 0.79 | GRIA1 (0.47) | GRIA1GRIA3GRIA4GRIA2GRIK5 | |
| SCHEMBL2971633 | 0.79 | GRIA1 (0.47) | GRIA1GRIA3GRIA4GRIA2GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049628-B1 | NONAPEPTIDE AND DECAPEPTIDE ANALOGS OF LHRH, USEFUL AS LHRH ANTAGONISTS, METHODS OF MAKING THEM, AND THEIR PHARMACEUTICAL USES | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| EP-0021234-B1 | NONAPEPTIDE AND DECAPEPTIDE DERIVATIVES OF LUTEINIZING HORMONE RELEASING HORMONE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1984-08-22 | — | — | EP | disclosed |
| US-4419347-A | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists | SYNTEX (U.S.A.) INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4341767-A | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists | SYNTEX INC. (US) | 1982-07-27 | — | — | US | disclosed |
| EP-0049628-A2 | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists, methods of making them, and their pharmaceutical uses | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| EP-0021234-A1 | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4234571-A | CONTRACEPTIVES, ANTIFERTILITY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1980-11-18 | — | — | US | disclosed |