Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.56 |
| ▸ | ACE | P12821 | 10/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PEPD | P12955 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696439 | 0.90 | ACE (0.55) | RENACEKDM4EF2LMNA | |
| SCHEMBL7272881 | 0.83 | ACE (0.55) | RENACEKDM4EF2LMNA | |
| SCHEMBL11031456 | 0.81 | ACE (0.54) | ACELMNALTA4HACE2 | |
| Hydrochloric Acid SCHEMBL7326358 | 0.81 | ACE (0.57) | RENACEKDM4EF2LMNA | |
| SCHEMBL10658196 | 0.80 | ACE (0.60) | RENACEKDM4EF2LMNA | |
| SCHEMBL19817050 | 0.80 | ACE (0.60) | RENACEKDM4EF2LMNA | |
| SCHEMBL13019815 | 0.80 | ACE (0.60) | RENACEKDM4EF2LMNA | |
| SCHEMBL11221776 | 0.79 | ACE (0.55) | ACELMNAACE2 | |
| SCHEMBL7271630 | 0.79 | ACE (0.50) | RENACEKDM4EF2LMNA | |
| SCHEMBL11031153 | 0.79 | ACE (0.47) | RENACEKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |