Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGAV | P06756 | 1/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11031456 | 0.89 | ACE (0.54) | ACELMNAACE2 | |
| SCHEMBL7264225 | 0.82 | ACE (0.61) | ACELMNAACE2 | |
| SCHEMBL7264237 | 0.82 | ACE (0.61) | ACELMNAACE2 | |
| SCHEMBL11031930 | 0.82 | ACE (0.55) | ACELMNAACE2 | |
| SCHEMBL11033719 | 0.81 | ACE (0.60) | ACELMNAACE2 | |
| SCHEMBL29696439 | 0.80 | ACE (0.55) | ACELMNAACE2 | |
| SCHEMBL11435575 | 0.80 | ACE (0.71) | ACEACE2 | |
| SCHEMBL3472327 | 0.80 | ACE (0.71) | ACEACE2 | |
| SCHEMBL29749309 | 0.80 | ACE (0.71) | ACEACE2 | |
| SCHEMBL11032956 | 0.80 | ACE (0.63) | ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316896-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0009183-B1 | PHOSPHORYL AMINOACID DERIVATIVES AND COMPOSITION FOR TREATING HYPERTENSION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0009183-A1 | Phosphoryl aminoacid derivatives and composition for treating hypertension containing the same | MERCK & CO. INC. (US) | 1980-04-02 | — | — | EP | disclosed |