Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387142 | 0.90 | HSD11B1 (0.51) | HSD11B1ALDH1A1TP53PKMHTT | |
| SCHEMBL4413278 | 0.82 | HSD11B1 (0.52) | HSD11B1ALDH1A1PKMHTTNLRP3 | |
| SCHEMBL22716411 | 0.82 | HSD11B1 (0.52) | HSD11B1ALDH1A1PKMHTTNLRP3 | |
| SCHEMBL4406817 | 0.80 | HSD11B1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2PKMHTT | |
| SCHEMBL4407255 | 0.79 | HSD11B1 (0.55) | HSD11B1ALDH1A1TP53SMN1; SMN2PKM | |
| SCHEMBL10677744 | 0.76 | HSD11B1 (0.63) | HSD11B1ALDH1A1PKMHTTNLRP3 | |
| SCHEMBL4414691 | 0.73 | HSD11B1 (0.57) | HSD11B1ALDH1A1SMN1; SMN2PKMHTT | |
| SCHEMBL10675268 | 0.73 | HSD11B1 (0.53) | HSD11B1ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL30444595 | 0.73 | S1PR2 (0.50) | — | |
| SCHEMBL27029539 | 0.73 | S1PR2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035046-B1 | NOVEL TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-02 | — | — | EP | disclosed |