Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 9/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129492 | 0.89 | SUV39H2 (0.41) | — | |
| SCHEMBL2143659 | 0.83 | MET (0.41) | — | |
| SCHEMBL108873 | 0.80 | PTGDR (0.37) | DGAT1 | |
| SCHEMBL2142224 | 0.78 | CCNE1 (0.37) | DGAT1 | |
| SCHEMBL31540053 | 0.76 | NTRK1 (0.38) | DGAT1ALDH1A1NPC1 | |
| SCHEMBL2143614 | 0.76 | NTRK1 (0.46) | DGAT1ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL26124012 | 0.75 | DGAT1 (0.36) | MTNR1AMTNR1BKLKB1DGAT1CACNA2D1 | |
| SCHEMBL2128838 | 0.74 | MAPT (0.43) | ALDH1A1MAPT | |
| SCHEMBL25426997 | 0.73 | GNRHR (0.43) | ALDH1A1NPC1USP2RAB9AMAPT | |
| SCHEMBL30508603 | 0.73 | GNRHR (0.43) | ALDH1A1NPC1USP2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424843-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | Novartis AG (CH) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |