Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | MGLL | Q99685 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033648 | 0.85 | GSK3A (0.49) | GSK3BGSK3AMGLLFAAHCYP4F2 | |
| SCHEMBL11030707 | 0.85 | ALDH1A1 (0.44) | GSK3BGSK3AMGLLFAAHMAPK1 | |
| SCHEMBL11033101 | 0.84 | GSK3A (0.48) | GSK3BGSK3AMGLLFAAHHSP90AA1 | |
| SCHEMBL16316860 | 0.79 | LOXL2 (0.44) | GSK3BMGLLCYP4F2CYP4A11MAPK1 | |
| SCHEMBL19658173 | 0.77 | KMT2A (0.44) | GSK3BMGLLCYP4F2CYP4A11MAPK1 | |
| SCHEMBL16426741 | 0.77 | LOXL2 (0.40) | GSK3BMGLLCYP4F2CYP4A11MAPK1 | |
| SCHEMBL14860981 | 0.76 | MAPK1 (0.48) | MGLLMAPK1ALDH1A1 | |
| SCHEMBL11030667 | 0.76 | GSK3A (0.49) | GSK3BGSK3AMGLLFAAHHSP90AA1 | |
| SCHEMBL79589 | 0.74 | MAPK1 (0.54) | MGLLFAAHHSP90AA1MAPK1ALDH1A1 | |
| SCHEMBL29354362 | 0.74 | MAPK1 (0.54) | MGLLFAAHHSP90AA1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536391-A | REACTING A PLASMIN HEAVY CHAIN WITH UROKINASE IN THE PRESENCE OF A COUPLING AGENT | OTSUKA PHARMACEUTICAL CO. (JP) | 1985-08-20 | — | — | US | disclosed |
| EP-0109653-A2 | Process for preparing urokinase complex | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-05-30 | — | — | EP | disclosed |